Match the mechanism of tolerance breakdown with the functional defect that could directly cause that tolerance breakdown to increase risk of autoimmunity. reversal of anergy in T cells у[ Выбрать ] FoxP3 gene defect AIRE gene defect high levels of IL-2 CTLA-4 gene defect Unregulated T cell proliferation Loss of Treg function [ Выбрать ] Significantly reduced negative selection [ Выбрать ] <
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